Kallikrein and prekallikrein determination in a number of pathological conditions using the Centrifichem analyzer

An improved method for the determination of kallikrein (K) and prekallikrein (PK) is described. The chromogenic substrate N-Benzoyl-L-Prolyl-L-Phenylalanyl-L-Arginyl-p-Nitroanilidhydrochlorid is used and adapted for routine determinations with the Centrifichem 500 analyzer. A group of 30 healthy persons are compared with 10 allergic patients, three patients with hereditary angioneurotic edema and three patients with migraine attacks and the normal and pathological values described and discussed.