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Updated: Aug 15, 2026

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
Published on: June 28, 2021
[Antienzyme function of the lungs in acute pancreatitis]
Abstract:
Experiments were made on 22 anesthetized dogs to examine the systemic and pulmonary hemodynamics, gas exchange and metabolic pulmonary function in pancreonecrosis. Metabolic pulmonary function was evaluated from arteriovenous difference according to elastase. In the early stages of experimental pancreatitis, the lungs were shown to inactivate elastase and to function as an active metabolic organ. Then depletion of antienzymatic pulmonary function is observed, which is accompanied by decompensation of the hemodynamics and gas exchange. Abnormality of antienzymaztic pulmonary function plays an important role in the pathogenesis of acute pancreatitis.
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