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Related Experiment Videos

Does mixing pancreatic enzyme microspheres (Pancrease) with food damage the enteric coating?

J W Sackman, K E Smith, D Y Graham

    Journal of Pediatric Gastroenterology and Nutrition
    |January 1, 1982
    PubMed
    Summary
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    Enteric-coated pancreatic enzymes mixed with acidic infant foods like applesauce may have reduced effectiveness. Parents should avoid certain foods when administering these enzymes to children with cystic fibrosis.

    Area of Science:

    • Biochemistry
    • Pediatrics
    • Gastroenterology

    Background:

    • Cystic fibrosis (CF) often causes malabsorption due to pancreatic insufficiency.
    • Pancreatic enzyme replacement therapy (PERT) is crucial for managing CF-related malabsorption.
    • Enzymes are commonly mixed with infant foods for administration to children.

    Purpose of the Study:

    • To evaluate the impact of infant foods on enteric-coated pancreatic enzyme microspheres.
    • To assess changes in enzyme activity and enteric coating integrity after in vitro incubation.

    Main Methods:

    • In vitro incubation of enteric-coated pancreatic enzyme microspheres with various infant foods.
    • Measurement of total recoverable enzyme activity.
    • Assessment of enteric coating thickness and integrity.

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    Main Results:

    • Incubation with neutral to alkaline foods (pH > 5) had no significant effect on enzyme activity or coating.
    • Incubation with acidic applesauce (pH 3.5) caused a minor reduction in enzyme activity and significantly reduced coating thickness.
    • Unprotected lipase was rapidly inactivated in acidic conditions, highlighting the importance of the enteric coating.

    Conclusions:

    • Acidic infant foods, such as applesauce, may compromise the integrity and efficacy of enteric-coated pancreatic enzymes.
    • The findings suggest a need for parental guidance on appropriate food choices when administering PERT.
    • Further research is needed to determine if these in vitro changes affect in vivo therapeutic outcomes.