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Related Experiment Videos

Subcutaneously implanted alginate as a continuous-release source of fluoride.

G M Whitford, J Ekstrand, R S Callan

    Journal of Dental Research
    |February 1, 1980
    PubMed
    Summary

    Alginate materials release fluoride for up to three weeks, effectively increasing fluoride levels in soft and hard tissues. This method offers a simple and economical approach for tissue fluoride elevation.

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    Area of Science:

    • Biomaterials Science
    • Dental Materials
    • Tissue Engineering

    Background:

    • Alginate is a widely used biomaterial in various medical and dental applications.
    • Fluoride incorporation into biomaterials can enhance tissue properties and therapeutic effects.
    • Controlled fluoride release from implants is desirable for localized treatment.

    Purpose of the Study:

    • To quantify fluoride concentrations in commercial alginate brands.
    • To evaluate the in vivo fluoride release kinetics from alginate implants.
    • To assess the efficacy of alginate implants for elevating tissue fluoride levels.

    Main Methods:

    • Analysis of fluoride content in seven alginate brands using established methods.
    • Subcutaneous implantation of alginate cylinders in animal models for acute and chronic studies.

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  • Monitoring of fluoride release over a three-week period.

    • Main Results:

    • Fluoride concentrations in alginate samples varied significantly, ranging from 8600 to 30,500 ppm.
    • Continuous fluoride release was observed from implanted alginate cylinders for up to three weeks.
    • The technique demonstrated successful elevation of fluoride levels in surrounding soft and hard tissues.

    Conclusions:

    • Commercial alginate materials possess substantial fluoride content.
    • Subcutaneously implanted alginate provides a sustained release of fluoride in vivo.
    • This technique presents a simple, economical, and effective method for increasing tissue fluoride levels.