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Leukemic iris infiltration.

K A Zakka, R D Yee, N Shorr

    American Journal of Ophthalmology
    |February 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

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    Acute lymphocytic leukemia can infiltrate the eye, causing hypopyon and glaucoma. Diagnostic paracentesis and anterior segment irradiation effectively treated these ocular complications in a pediatric patient.

    Area of Science:

    • Ophthalmology
    • Pediatric Oncology
    • Hematology

    Background:

    • Acute lymphocytic leukemia (ALL) is a common childhood cancer.
    • Ocular involvement in ALL can lead to significant visual morbidity.
    • Iris infiltration, hypopyon, and glaucoma are potential ocular manifestations of ALL.

    Observation:

    • A 7-year-old boy with ALL presented with ocular symptoms including iris infiltration, blood-streaked hypopyon, and elevated intraocular pressure.
    • Anterior chamber paracentesis was performed for diagnostic cytology.
    • Cytologic analysis utilized both millipore filter with Papanicolaou stain and dried smear with Wright's stain.

    Findings:

    • Wright's stain provided superior cellular detail compared to the millipore filter technique.
    • Cytologic diagnosis confirmed leukemic infiltration of the anterior chamber.

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  • Irradiation of the anterior segment led to the resolution of leukemic iris infiltration, hypopyon, and glaucoma.

    • Implications:

    • Early diagnosis of ocular leukemia through cytologic analysis is crucial.
    • Anterior segment irradiation is an effective treatment for ocular leukemia.
    • Prompt management of ocular leukemia can prevent vision loss in pediatric patients with ALL.