Acute lymphoblastic leukemia following Hodgkin's disease

Over 100 instances of acute leukemia have been reported in the course of Hodgkin's disease. The type of leukemia almost always is nonlymphoblastic. Only five well documented cases of acute lymphoblastic leukemia (ALL) have been found by us in the world literature. One case who developed ALL six years after intensive radiotherapy for Hodgkin's disease is herewith reported. The patient responded to treatment with Prednisone, Vincristine and intrathecal methotrexate and maintained a complete remission on 6-mercaptopurine for nine months. When last seen, the bone marrow revealed a mild increase in blasts indicative of an early relapse.