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[Myoglobin increase during tocolysis (author's transl)].

W Lechner, F Dienstl, W Poewe

    Wiener Klinische Wochenschrift
    |July 4, 1980
    PubMed
    Summary
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    Intravenous tocolysis using hexoprenalin for premature labor can elevate serum myoglobin levels in pregnant patients. This finding impacts the diagnostic utility of myoglobin for myocardial necroses during pregnancy.

    Area of Science:

    • Biochemistry
    • Cardiology
    • Obstetrics

    Context:

    • Premature labor management involves tocolytic agents.
    • Hexoprenalin, a beta-sympathomimetic, is used for tocolysis.
    • Serum myoglobin is a biomarker for myocardial injury.

    Purpose:

    • To investigate serum myoglobin levels during hexoprenalin-induced tocolysis.
    • To assess the impact of tocolysis on myoglobin as a cardiac biomarker.

    Summary:

    • Serum myoglobin was measured in 22 pregnant patients receiving intravenous hexoprenalin for premature labor.
    • Elevated myoglobin levels (26-140% increase) were observed in 6 patients; one showed a 20-fold rise.
    • These myoglobin level changes occurred within 2-4 hours post-infusion initiation.

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    Impact:

    • Findings suggest that hexoprenalin-induced tocolysis can cause transient myoglobin elevations.
    • This complicates the interpretation of serum myoglobin for diagnosing myocardial necroses in pregnant patients.
    • Highlights the need for careful consideration of confounding factors in cardiac biomarker assessment during pregnancy.