Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Fibronectin and atherosclerosis.

S Stenman, K von Smitten, A Vaheri

    Acta Medica Scandinavica. Supplementum
    |January 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Fibronectin, a glycoprotein in connective tissue, is abundant in atherosclerotic lesions. Its presence indicates connective tissue formation and suggests a role in the development of atherosclerosis.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Epidemiology of Sindbis virus infections in Finland 1981-96: possible factors explaining a peculiar disease pattern.

    Epidemiology and infection·2002
    Same author

    Tissue plasminogen activator as a key effector in neurobiology and neuropathology.

    Biochemical Society transactions·2002
    Same author

    Antibody status to HHV-6 in children with leukaemia.

    Leukemia·2002
    Same author

    Mapping of B-cell epitopes in the nucleocapsid protein of Puumala hantavirus.

    Viral immunology·2002
    Same author

    [Gene amplification methods in viral diagnostics].

    Duodecim; laaketieteellinen aikakauskirja·2002
    Same author

    Chlamydia trachomatis infection in mothers with preterm delivery and in their newborn infants.

    APMIS : acta pathologica, microbiologica, et immunologica Scandinavica·2002
    Same journal

    Giving life, giving death: ethical problems of high-technology medicine.

    Acta medica Scandinavica. Supplementum·1988
    Same journal

    Potential importance of the muscles for the development of insulin resistance in obesity.

    Acta medica Scandinavica. Supplementum·1988
    Same journal

    Potential role of adipose tissue for the development of insulin resistance in obesity.

    Acta medica Scandinavica. Supplementum·1988
    Same journal

    Mechanisms associating body fat distribution to glucose intolerance and diabetes mellitus: window with a view.

    Acta medica Scandinavica. Supplementum·1988
    Same journal

    Physical training and changes in regional adipose tissue distribution.

    Acta medica Scandinavica. Supplementum·1988
    Same journal

    Hormonal abnormalities in obesity.

    Acta medica Scandinavica. Supplementum·1988
    See all related articles

    Area of Science:

    • Biochemistry
    • Cell Biology
    • Pathology

    Background:

    • Fibronectin is a polymorphic glycoprotein found in plasma, body fluids, and connective tissue, existing in soluble and insoluble forms.
    • Insoluble fibronectin serves as a substrate for cell attachment and migration, while soluble fibronectin interacts with fibrin and collagen.
    • Fibronectin is present in arterial walls, including the sub-endothelium, smooth muscle cell matrix, and adventitia.

    Purpose of the Study:

    • To investigate the presence and distribution of fibronectin in human arteries, particularly in atherosclerotic lesions.
    • To determine if fibronectin is associated with connective tissue formation in atherosclerosis.
    • To explore the potential role of fibronectin in the pathogenesis of atherosclerosis.

    Main Methods:

    Related Experiment Videos

  • Immunohistological techniques were employed to detect and localize fibronectin.
  • The study examined fibronectin distribution in normal arterial tissues and experimentally induced atherosclerotic lesions.

    • Main Results:

    • Fibronectin was detected in the sub-endothelium, smooth muscle cell matrix, and adventitia of arteries.
    • Fibronectin was found to be prominent in the intima of atherosclerotic lesions, especially in developing fibrous plaques.
    • Fibronectin was also prominent in experimentally induced atherosclerotic lesions.

    Conclusions:

    • Fibronectin is a significant component of atherosclerotic lesions, particularly during plaque development.
    • The presence of fibronectin suggests it is an indicator of connective tissue formation in atherosclerotic processes.
    • Fibronectin may play a role in the pathogenesis of atherosclerosis.