Aminoglycoside nephrotoxicity in dogs: dependence on drug, dose and regimen

In female mongrel dogs nephrotoxicity of three aminoglycosides (gentamicin, tobramycin and netilmicin) was compared with relation to the cortical aminoglycoside concentration. A standard regimen of 45 mg/kg/day with constant intravenous infusion and once daily dosing of each aminoglycoside was used, and in subsequent dogs netilmicin daily dose was increased to an average of 73 mg/kg/day.