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Priapism complicating chronic granulocytic leukemia

R Suri, J M Goldman, D Catovsky

    American Journal of Hematology
    |January 1, 1980
    PubMed
    Summary

    Priapism can be an early indicator of chronic granulocytic leukemia (CGL). Prompt reduction of high leukocyte counts in CGL patients presenting with priapism is crucial for effective management.

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    Area of Science:

    • Hematology
    • Oncology
    • Urology

    Background:

    • Priapism, a prolonged erection, can be a rare presenting symptom of hematologic malignancies.
    • Chronic granulocytic leukemia (CGL) is a myeloproliferative neoplasm characterized by elevated white blood cell counts.

    Purpose of the Study:

    • To investigate the association between priapism and chronic granulocytic leukemia (CGL).
    • To evaluate the incidence and management outcomes of priapism in CGL patients.

    Main Methods:

    • Retrospective review of ten male patients diagnosed with CGL who presented with priapism.
    • Analysis of patient histories, leukocyte counts, and treatment modalities.

    Main Results:

    • Ten male patients with CGL presented with priapism, with an estimated incidence of 1%-2% among male CGL patients.

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  • All patients exhibited significantly elevated leukocyte counts (mean 380 X 10(9)/liter).
  • Prompt reduction of leukocyte counts appeared more beneficial than surgical interventions.

    • Conclusions:

    • Priapism is a potential, albeit rare, presenting sign of CGL.
    • Effective management of CGL-associated priapism involves prompt reduction of leukocyte count.