Neuromuscular tissue defects and antropyloric dysfunction in peptic ulcer

Pathomorphology of antropyloric wall in peptic ulcer disease includes: 1. Asymmetrical hypertrophy of the muscle, 2. Reversible changes and irreversible damage of a part of muscle cells and ganglia, 3. Tissue infiltration: Eosinophils and mast cells, 4. Scar formation (fibrosis) in the muscle and submucosa, 5. Edema formation of the submucosa. This is not found in controls but constant in peptic ulcer disease. Changes do not depend upon the ulcer site, size and number and are common in the antropyloric wall of all patients with peptic ulcer but most pronounced in gastric ulcer.