Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Human embryonic somatomedin

V R Sara, K Hall, C H Rodeck

    Proceedings of the National Academy of Sciences of the United States of America
    |May 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Total uterine artery blood volume flow rate in nulliparous women is associated with birth weight and gestational age at delivery.

    Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2016
    Same author

    The relationship between body mass index and mid-arm circumference in a pregnant population.

    Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology·2011
    Same author

    Antenatal screening for Down's syndrome using the Integrated test at two London hospitals.

    Journal of medical screening·2009
    Same author

    Local delivery of VEGF adenovirus to the uterine artery increases vasorelaxation and uterine blood flow in the pregnant sheep.

    Gene therapy·2008
    Same author

    Association of isolated short femur in the mid-trimester fetus with perinatal outcome.

    Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2008
    Same author

    Urinary excretion of inositol phosphoglycan P-type in gestational diabetes mellitus.

    Diabetic medicine : a journal of the British Diabetic Association·2007
    Same journal

    Chemotactic self-organization captures the dynamics of mammalian hair follicle patterning.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    Same journal

    Tomographic imaging of superconducting order using particle-hole interference.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    Same journal

    Inhibitory potential of autologous neutralizing antibodies sets quantitative limits on the rebound-competent HIV-1 reservoir.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    Same journal

    Inferring epidemiological parameters under an infectious phylogeography model with visitor dynamics.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    Same journal

    Analytical modeling for suction cup designs for skin-interfaced wearable devices.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    Same journal

    Improving cell-free metabolism through direct integration of artificial respiratory chains.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    See all related articles

    Researchers developed a new assay to measure fetal brain somatomedin A (RRA-SMA), finding significantly higher levels in fetuses than adults. These levels correlate with birth weight and may indicate embryonic somatomedin presence.

    Area of Science:

    • Endocrinology
    • Developmental Biology
    • Biochemistry

    Background:

    • Adult somatomedins are typically undetectable in fetal circulation.
    • Previous methods could not accurately quantify fetal somatomedin levels.

    Purpose of the Study:

    • To develop and validate a radioreceptor assay for fetal brain somatomedin A (RRA-SMA).
    • To investigate the concentration and significance of RRA-SMA in fetal and adult human circulation.
    • To assess RRA-SMA as a potential biomarker for fetal growth and development.

    Main Methods:

    • Development of a radioreceptor assay (RRA) using human fetal brain plasma membrane and somatomedin A as the ligand.
    • Measurement of RRA-SMA levels in fetal and adult human serum samples.
    • Comparison of RRA-SMA levels with adult somatomedin levels measured by radioimmunoassay.

    Related Experiment Videos

  • Correlation analysis of RRA-SMA with birth weight and length in healthy newborns.

    • Main Results:

    • Fetal circulation exhibited approximately 4-fold higher RRA-SMA concentrations compared to adults.
    • RRA-SMA levels in newborns at birth fell within the adult range.
    • Adult somatomedins were undetectable in fetuses and below adult range at birth.
    • Decreased RRA-SMA levels were observed in fetuses with clinical disorders.
    • Significant positive correlation found between serum RRA-SMA and birth weight/length in healthy newborns.

    Conclusions:

    • Evidence suggests the presence of an embryonic somatomedin in humans.
    • The fetal brain RRA-SMA assay is a reliable indicator of fetal growth.
    • RRA-SMA may serve as a valuable index for monitoring fetal well-being and development.