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Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
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[Clinical significance of HDL-cholesterol]

W Reuter, W Herrmann

    Zeitschrift Fur Die Gesamte Innere Medizin Und Ihre Grenzgebiete
    |July 15, 1981
    PubMed

    Insights

    High-Density Lipoprotein (HDL) cholesterol plays a vital role in removing cholesterol from vessels, offering cardio-protection. Maintaining optimal HDL levels is crucial for assessing and managing coronary risk.

    Area of Science:

    • Metabolic research
    • Cardiovascular science

    Context:

    • High-Density Lipoprotein (HDL) cholesterol's metabolic functions are explored.
    • HDL facilitates cholesterol efflux from vessels and hepatic catabolism via mechanisms like LCAT-substrate activity and competitive LDL inhibition.

    Purpose:

    • To elucidate the metabolic role of HDL and HDL-cholesterol.
    • To highlight the cardio-protective effects of HDL-cholesterol.
    • To establish the diagnostic and prognostic significance of HDL-cholesterol levels in relation to coronary risk.

    Summary:

    • HDL-cholesterol exhibits cardio-protective properties, with reduced levels observed in cardiovascular diseases.
    • Epidemiological, clinical, angiographical, and experimental studies confirm HDL-cholesterol's association with cardiovascular health.
    • Determination of HDL-cholesterol, alongside LDL-cholesterol calculation, aids in assessing coronary risk.

    Impact:

    • Provides reference ranges for HDL-cholesterol in males (35-55 mg/dl) and females (45-65 mg/dl) for standard risk assessment.
    • Identifies various factors and diseases influencing HDL-cholesterol concentration.
    • Suggests that lifestyle modifications (physical conditioning, nutrition, weight reduction) and medications can increase HDL-cholesterol levels.

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