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Evaluation of a combined oestrogen-progestogen injectable contraceptive
Summary
This study found that a monthly injection of medroxyprogesterone acetate and oestradiol cypionate (Cyclo-Provera) was an effective and acceptable contraceptive for Black women. No pregnancies occurred, and side effects were minimal, making it a promising addition to available birth control methods.
Area of Science:
- Reproductive Health
- Endocrinology
- Contraception
Background:
- Combined injectable contraceptives offer long-acting reversible contraception.
- Assessing the efficacy and tolerability of specific formulations is crucial for expanding contraceptive options.
Purpose of the Study:
- To evaluate the safety, efficacy, and acceptability of a combined monthly injectable contraceptive (medroxyprogesterone acetate and oestradiol cypionate) in Black women of reproductive age.
Main Methods:
- A prospective study involving 120 Black women of reproductive age.
- Monthly administration of 50 mg medroxyprogesterone acetate and 10 mg oestradiol cypionate for 1 to 18 months.
- Monitoring for side effects, pregnancies, and menstrual bleeding patterns.
Main Results:
- No pregnancies were reported across 575 cycles studied.
- The contraceptive regimen demonstrated an acceptable menstrual bleeding pattern for most participants.
- Amenorrhoea (absence of menstruation) occurred in 15.8% of patients, but only 2.5% discontinued treatment due to this side effect.
- The incidence of amenorrhoea decreased with continued use of the injectable contraceptive.
Conclusions:
- The combined injectable contraceptive (medroxyprogesterone acetate and oestradiol cypionate) is a safe and effective method of birth control for Black women.
- The regimen is well-tolerated, with a high degree of acceptability despite occasional amenorrhoea.
- This injectable contraceptive represents a valuable addition to the range of available family planning methods, warranting further investigation into specific aspects.