Anti-H-2Dd antibodies cross-react with HLA--A11 and Aw31

Significant correlation was found between the cytotoxicity scoring grade (CSG) of an alloimmune mouse anti--H--2Dd serum with the presence of HLA--A11 and HLA--Aw31 on human lymphocytes. The finding shows a new type of H--2/HLA cross-reactivity and a hitherto unknown relationship (XENO-CREG) between two HLA antigens.