Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cardiac abnormalities after AMSA administration

L J Steinherz, P G Steinherz, D Mangiacasale

    Cancer Treatment Reports
    |March 1, 1982
    PubMed
    Summary

    Amsacrine (AMSA) can cause cardiac abnormalities, including congestive heart failure, in cancer patients. The risk increases with higher cumulative doses of AMSA and prior anthracycline treatment.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Analysis of posterior uterus approach combined with vascular occlusion in placenta percreta].

    Zhonghua fu chan ke za zhi·2026
    Same author

    [Liver function and distribution of liver fibrosis in older adults aged 65 years and above in 18 longevity areas in China].

    Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi·2026
    Same author

    Effect of Blood-Air Contact on Blood-Based Perfusates for Ex Vivo Lung Perfusion Using an In Vitro Approach<sup></sup>.

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
    Same author

    Impact of daratumumab refractoriness on clinical outcomes following CAR T-cell therapy for relapsed refractory multiple myeloma.

    Blood cancer journal·2025
    Same author

    [Progress of researches on mechanisms underlying immune escape of <i>Plasmodium</i>].

    Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control·2025
    Same author

    [Distribution characteristics and long-term change trend of body mass index in Chinese older adults aged 65 years and above].

    Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]·2025

    Area of Science:

    • Cardiology
    • Oncology
    • Pharmacology

    Background:

    • Anthracyclines and amsacrine (AMSA) are chemotherapeutic agents with known cardiotoxicity.
    • Assessing the cardiac impact of AMSA, particularly in conjunction with anthracyclines, is crucial for patient safety.

    Purpose of the Study:

    • To evaluate the incidence and characteristics of cardiac abnormalities induced by amsacrine (AMSA).
    • To identify factors influencing AMSA-induced cardiotoxicity, including prior anthracycline exposure and AMSA administration parameters.

    Main Methods:

    • Echocardiographic assessment of cardiac function in patients receiving AMSA.
    • Correlation of cardiac abnormalities with cumulative anthracycline dose, AMSA dose, and administration rate.
    • Analysis of patient outcomes based on treatment regimens.

    Main Results:

    • AMSA induced echocardiographic abnormalities in 18 of 27 patients; 7 developed clinical congestive heart failure.
    • Cardiac abnormalities were associated with higher cumulative anthracycline doses and specific AMSA dosing strategies (e.g., >200 mg/m2 within 48 hours, or after >400 mg/m2 anthracyclines).
    • A combined dose of ≥900 mg/m2 of anthracyclines and AMSA was linked to a higher incidence of abnormalities (13/14 patients).

    Conclusions:

    • AMSA administration can lead to significant cardiac abnormalities and congestive heart failure.
    • Cardiotoxicity is dose-dependent and influenced by prior anthracycline exposure.
    • Cardiac abnormalities may be reversible upon prompt treatment and drug cessation.

    Related Experiment Videos