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Related Experiment Videos

Sciatica in CGL: a sign of transformation

G E Holdstock, M Chisholm

    Clinical and Laboratory Haematology
    |January 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Sciatica and back pain in chronic granulocytic leukemia patients may indicate disease acceleration. This symptom can herald the terminal stage, with all studied patients eventually succumbing to the illness.

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    Area of Science:

    • Hematology
    • Oncology
    • Neurology

    Background:

    • Chronic granulocytic leukemia (CGL) is a myeloproliferative neoplasm.
    • Leukemic infiltration of bone can cause pain.
    • Neurological complications in CGL are not well-documented.

    Purpose of the Study:

    • To investigate the significance of sciatica and back pain in CGL patients.
    • To determine if these symptoms are associated with disease progression.

    Main Methods:

    • Case series presentation of six CGL patients.
    • Clinical observation of symptom development and disease course.
    • Radiological and post-mortem examination for bony infiltration.

    Main Results:

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  • All six patients developed sciatica and back pain.
  • Other signs of accelerated CGL appeared within months.
  • Radiological or post-mortem evidence of bony infiltration was found in four patients.
  • All patients died, indicating a poor prognosis.

    • Conclusions:

    • Sciatica and back pain may be indicative of accelerated CGL.
    • These symptoms could herald the terminal stage of the disease.
    • Leukemic bone infiltration is a potential cause of these symptoms.