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Acute renal failure in McArdle's disease
Southern Medical Journal
|March 1, 1982
Summary
McArdle's disease, a genetic disorder causing muscle issues, can lead to acute kidney injury through rhabdomyolysis. This rare complication arises from severe muscle breakdown, even in patients aware of their exercise limitations.
Area of Science:
- Neurology
- Nephrology
- Metabolic Myopathies
Background:
- McArdle's disease is a glycogen storage disease affecting skeletal muscle due to myophosphorylase deficiency.
- It is known to cause intermittent myoglobinuria, but severe renal complications are uncommon.
Observation:
- A 35-year-old male presented with acute renal failure.
- The patient was diagnosed with rhabdomyolysis secondary to McArdle's disease.
Findings:
- This case highlights a rare instance of acute renal failure in McArdle's disease.
- Severe muscle exertion, despite recognized limitations, can trigger myoglobinuria severe enough to damage kidneys.
Implications:
- Patients with McArdle's disease may be at risk for acute kidney injury following strenuous activity.
- Understanding this association is crucial for managing patients with McArdle's disease and preventing renal complications.