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The major histocompatibility complex

F B Vasey, L R Espinoza, T S Bocanegra

    Annals of Clinical and Laboratory Science
    |January 1, 1982
    PubMed
    Summary
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    This study reveals strong links between specific Human Leukocyte Antigen (HLA) markers and spondyloarthropathies, particularly psoriatic arthritis. HLA B27 is strongly associated with spinal involvement in these conditions.

    Area of Science:

    • Immunogenetics
    • Rheumatology
    • Human Leukocyte Antigen (HLA) System

    Background:

    • The Human Leukocyte Antigen (HLA) system, controlled by the major histocompatibility complex, involves cell surface antigens crucial for transplantation and disease association.
    • Spondyloarthropathies, including ankylosing spondylitis, Reiter's syndrome, psoriatic arthritis, and inflammatory bowel disease-associated arthritis, show a close association with specific HLA antigens.

    Purpose of the Study:

    • To investigate the prevalence of specific HLA antigens in patients with seronegative arthritis.
    • To determine the association of HLA antigens with different types of spondyloarthropathies and clinical manifestations like spinal involvement.

    Main Methods:

    • Clinical and radiographic evaluation of 310 unrelated Caucasian patients with seronegative arthritis.

    Related Experiment Videos

  • HLA-A, B, C, and DR typing using the microdroplet lymphocyte cytotoxicity test.

    • Main Results:

    • Statistically increased prevalences of HLA-A26, HLA-B27, and HLA-Bw38 were observed.
    • HLA-B27 was significantly associated with spinal involvement (90% in ankylosing spondylitis, p < 0.0001).
    • HLA-A26 and HLA-Bw38 were found in 23% (p < 0.001) and 38% (p < 0.0001) of psoriatic arthritis patients, respectively.
    • HLA-DRw4 and HLA-DRw7 were increased in psoriatic arthritis patients (52%, p < 0.03 and 39%, p < 0.04).
    • HLA-B7 was frequently observed in spondyloarthritis patients with spinal involvement who lacked HLA-B27.

    Conclusions:

    • The study reinforces the significant association between specific Human Leukocyte Antigen (HLA) antigens and the development of spondyloarthropathies.
    • Specific HLA markers like B27, A26, Bw38, DRw4, and DRw7 are linked to different forms and manifestations of spondyloarthropathies.