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Diffuse cutaneous reticulohistiocytosis

D K Goette, R B Odom, J E Fitzwater

    Archives of Dermatology
    |March 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    This case study highlights a rare skin condition, multicentric reticulohistiocytosis, presenting without joint involvement. The eruption resolved spontaneously before the patient developed leukemia, suggesting a potential spectrum of disease.

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    Area of Science:

    • Dermatology
    • Oncology
    • Pathology

    Background:

    • Multicentric reticulohistiocytosis (MRH) is a rare systemic histiocytic disorder typically associated with arthritis.
    • Cutaneous manifestations of MRH can vary, including papules, nodules, and plaques.

    Observation:

    • A 65-year-old man presented with a year-long, asymptomatic, diffuse cutaneous eruption of reddish-brown papules.
    • Skin lesions exhibited morphologic, light microscopic, and ultrastructural features characteristic of MRH.
    • The patient showed no clinical, laboratory, or radiographic evidence of arthritis or systemic involvement.

    Findings:

    • The cutaneous eruption of MRH resolved spontaneously after 17 months.
    • Subacute myelogenous leukemia developed in the patient several weeks after the skin lesions involuted.

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  • Histopathological findings were consistent with MRH, despite the absence of systemic disease.

    • Implications:

    • This case suggests that diffuse cutaneous reticulohistiocytosis without systemic involvement may represent a distinct clinical expression within the spectrum of MRH.
    • The findings support the hypothesis that isolated reticulohistiocytomas, diffuse cutaneous reticulohistiocytosis, and systemic MRH share common etiologic and pathogenetic mechanisms.
    • Further research is warranted to elucidate the relationship between cutaneous histiocytic disorders and hematologic malignancies.