Chemical changes during formation and maturation of human deciduous enamel

The appearance and chemical composition of a number of developing human deciduous incisors indicated that the enamel passes through the following four developmental stages: 1. Partially mineralized matrix is secreted and some extracellular breakdown occurs. 2. Selective replacement of matrix proteins by tissue fluid begins. 3. Almost all of the matrix protein is replaced by tissue fluid and an influx of calcium phosphate occurs. 4. The enamel becomes almost fully mineralized, mature and hard. These stages of development are similar to those described in rat and bovine tissue. the number of stages simultaneously present in a single tooth differed from rat and bovine enamel, however, as did the rate of change in amino acid composition from developing to mature tissue.