Changes in lipoprotein cholesterol distribution in weight-stable postjejuno-ileal bypass patients

The influence of the jejuno-ileal bypass procedure upon serum lipoproteins was investigated. Lipoprotein cholesterol distribution was measured in 12 jejuno-ileal bypass subjects. The results were compared to 12 obese controls and 12 normal weight controls. In the bypass group, total cholesterol and low density lipoprotein cholesterol concentration was significantly reduced compared to both control groups. The high density lipoprotein cholesterol concentration in the bypass group was not significantly different when compared to the obese control group and in fact both obese groups had high density lipoprotein cholesterol levels significantly less than the normal weight controls. In the bypass group, the high density lipoprotein/low density lipoprotein cholesterol ratio was significantly increased compared to both control groups. These findings suggest a decreased atherogenic potential in jejuno-ileal bypass patients.