Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Developmentally regulated mRNAs in mouse liver

R K Barth, K W Gross, L C Gremke

    Proceedings of the National Academy of Sciences of the United States of America
    |January 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Analysis of the calcium paradox of renin secretion.

    American journal of physiology. Renal physiology·2018
    Same author

    Regional heritability mapping method helps explain missing heritability of blood lipid traits in isolated populations.

    Heredity·2015
    Same author

    Conditional deletion of p53 and Rb in the renin-expressing compartment of the pancreas leads to a highly penetrant metastatic pancreatic neuroendocrine carcinoma.

    Oncogene·2013
    Same author

    Calcium/NFAT signalling promotes early nephrogenesis.

    Developmental biology·2011
    Same author

    Expression and regulation of the renin gene.

    Trends in cardiovascular medicine·2011
    Same author

    Antipsychotic drugs dose-dependently suppress the spontaneous hyperactivity of the chakragati mouse.

    Neuroscience·2010
    Same journal

    Chemotactic self-organization captures the dynamics of mammalian hair follicle patterning.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    Same journal

    Tomographic imaging of superconducting order using particle-hole interference.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    Same journal

    Inhibitory potential of autologous neutralizing antibodies sets quantitative limits on the rebound-competent HIV-1 reservoir.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    Same journal

    Inferring epidemiological parameters under an infectious phylogeography model with visitor dynamics.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    Same journal

    Analytical modeling for suction cup designs for skin-interfaced wearable devices.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    Same journal

    Improving cell-free metabolism through direct integration of artificial respiratory chains.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    See all related articles

    Mouse liver abundant messenger RNAs (mRNAs) are developmentally regulated, with distinct expression periods during development. Not all abundant liver mRNAs share common developmental control, indicating complex gene regulation.

    Area of Science:

    • Molecular Biology
    • Developmental Biology
    • Genetics

    Background:

    • Mouse liver contains 10-12 abundant tissue-specific messenger RNAs (mRNAs).
    • These mRNAs are present at high concentrations (12,000-15,000 copies per cell).

    Purpose of the Study:

    • To investigate the developmental regulation of abundant liver mRNAs.
    • To determine the expression patterns of specific abundant liver mRNAs during development.

    Main Methods:

    • In vitro translation to assess mRNA regulation.
    • Quantitative analysis using specific cloned probes for mRNA expression.
    • Tracking developmental time course of five abundant liver mRNAs.

    Main Results:

    • Abundant liver mRNAs are developmentally regulated.

    Related Experiment Videos

  • At least three distinct periods of mRNA detectability exist: pre-conception, birth, and sexual maturity onset.
  • One specific mRNA (p54 mRNA) shows over a 1000-fold increase one day before birth.
  • Results suggest differential developmental regulation among abundant liver mRNAs.

    • Conclusions:

    • Abundant liver mRNAs are not uniformly regulated during development.
    • Multiple regulatory mechanisms likely control the expression of these genes.
    • Understanding these mechanisms is crucial for liver development research.