Multiple splenic aspergillomas in a patient with acute lymphoblastic leukemia

A case of multiple splenic aspergillomas (mycetomas) without systemic involvement is a patient with acute lymphoblastic leukemia is described. The patient underwent splenectomy without concomitant antifungal therapy. There has been no recurrence of the disease for over two years. Granulocytopenia and airborn contamination may have played a role in the acquisition of this disease. The value of serology, radionuclide scans and cultures in the diagnosis of Aspergillus infections is explored. The role of granulocyte transfusions, antifungal chemotherapy and the achievement of bone marrow remission in localization of the fungal disease is discussed.