The effect of pirenzepine on esophageal motility

The effect of pirenzepine on esophageal motility was studied in ten healthy volunteers by manometry. Pirenzepine reduces lower esophageal sphincter pressure (LESP), amplitude, and duration of esophageal contractions, but it increases velocity of propagation of esophageal contractions. On the other hand, it is known that pirenzepine inhibits gastric acid secretion. Therefore, the reduction of contractile force in the esophagus caused by pirenzepine does not necessarily mean an increased risk of peptic gastroesophageal reflux.