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A neural cell adhesion molecule from human brain

D A McClain, G M Edelman

    Proceedings of the National Academy of Sciences of the United States of America
    |October 1, 1982
    PubMed
    Summary
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    Researchers identified human neural cell adhesion molecule (N-CAM) in developing brains using a mouse antibody. This discovery opens avenues for studying N-CAM's role in neurological disorders.

    Area of Science:

    • Neuroscience
    • Molecular Biology
    • Immunology

    Background:

    • Neural cell adhesion molecules (CAMs) are crucial for neuronal development and function.
    • Understanding the specific CAMs present in the human brain is essential for neurological research.

    Purpose of the Study:

    • To characterize and purify a specific antigen from embryonic and neonatal human brain tissue.
    • To identify this antigen by comparing it to known neural cell adhesion molecules.

    Main Methods:

    • Utilized a cross-reactive monoclonal antibody targeting mouse neural cell adhesion molecule (N-CAM).
    • Purified the antigen from human brain samples.
    • Analyzed molecular weight, sialic acid content, amino acid composition, and peptide fragments.
    • Assessed reactivity with anti-CAM antibodies and aggregation assays.

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    Main Results:

    • Successfully purified and characterized an antigen from human brain.
    • Identified the antigen as human neural cell adhesion molecule (N-CAM) based on multiple biochemical and immunological criteria.
    • Confirmed N-CAM's aggregation activity in cell and membrane vesicle assays.

    Conclusions:

    • Human N-CAM has been identified and characterized in embryonic and neonatal brain tissue.
    • These findings provide a foundation for investigating the role of N-CAM in neurological disorders.