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Computed tomography in the elderly: I. The normal population

R J Jacoby, R Levy, J M Dawson

    The British Journal of Psychiatry : the Journal of Mental Science
    |March 1, 1980
    PubMed
    Summary
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    This study presents computed tomographic (CT) and psychometric data from healthy older adults. Findings suggest differences in normative brain imaging data and a link between brain atrophy and cognitive function in aging.

    Area of Science:

    • Neuroimaging
    • Gerontology
    • Psychometrics

    Background:

    • Establishing normative data for brain imaging in aging populations is crucial.
    • Previous computed tomographic (CT) studies have reported varying results on age-related brain changes.
    • Methodological challenges in acquiring normative CT data require careful consideration.

    Purpose of the Study:

    • To present computed tomographic (CT) and psychometric findings in healthy community-dwelling older adults.
    • To highlight the necessity of normative CT data for comparative studies.
    • To discuss the methodological considerations in obtaining such data.

    Main Methods:

    • Computed tomography (CT) scans were performed on 50 healthy individuals over 60 years old.
    • Psychometric assessments included tests of memory and orientation.

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  • Ventricular size and global cortical atrophy were quantified from CT images.

    • Main Results:

    • Measures of ventricular size in this cohort were generally larger than previously reported.
    • Observed age-related variation in ventricular size was less pronounced than in prior studies.
    • A significant inverse relationship was identified between cortical atrophy ratings and memory/orientation test performance.

    Conclusions:

    • The findings provide a basis for comparing brain structure and function in healthy aging with psychiatric patient groups.
    • The study underscores potential discrepancies in normative CT data and highlights the relationship between brain structure and cognition in older adults.