Chronic herpes simplex infection in cutaneous T-cell lymphomas

Therapeutically unresponsive erosive or ulcerative lesions caused by the herpes simplex virus developed in five patients with advanced cutaneous T-cell lymphoma. The chronic progressive character of the herpetic infection probably was the consequence of immunosuppression resulting from advanced lymphoma or its treatment. Herpes simplex infection should be considered in the differential diagnosis of cutaneous ulcerations in patients with cutaneous T-cell lymphomas.