Effect of the antidepressant drug-Stelazine on lymphocyte capping

The antidepressant agent, Stelazine (trifluoroperazine dihydrochloride), is known to cause inactivation of the calcium-binding protein, calmodulin. We report here that this drug in the concentration range of 5 x 10(-5) M to 10(-6) M causes remarkable inhibitory effets on ligand-induced T-lymphocyte receptor capping. The possible involvement of calmodulin in the regulation of lymphocyte surface receptor movement is therefore implicated.