Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Thymosin administration in autoimmune disorders

M T Lavastida, A L Goldstein, J C Daniels

    Thymus
    |February 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Maternal and neonatal outcome of women before vs. after bariatric surgery: A single tertiary center experience.

    American journal of surgery·2022
    Same author

    eTEP inferior access with tailored retromuscular dissection for small to mid-sized umbilical hernia repair with or without inguinal hernia: early experience.

    Hernia : the journal of hernias and abdominal wall surgery·2022
    Same author

    How-we-do-it: the repair of postoperative ventral hernias after a Mercedes abdominal incision.

    Langenbeck's archives of surgery·2021
    Same author

    Successful management of the open abdomen with hydrocolloid dressing in a resource-constrained setting.

    Hernia : the journal of hernias and abdominal wall surgery·2020
    Same author

    ACTUALITIES IN ENDOCRINOLOGY- PARATHYROID IMAGING.

    Acta endocrinologica (Bucharest, Romania : 2005)·2019
    Same author

    Managed and Wild Bee Flower Visitors and Their Potential Contribution to Pollination Services of Low-Chill Highbush Blueberry (Vaccinium corymbosum L.; Ericales: Ericaceae).

    Journal of economic entomology·2018

    Thymosin fraction 5 treatment increased T lymphocytes and reduced serum cytotoxicity in patients with autoimmune disorders. Three patients showed clinical improvement, suggesting potential therapeutic benefits for conditions like lupus and rheumatoid arthritis.

    Area of Science:

    • Immunology
    • Autoimmune Diseases
    • Pharmacology

    Background:

    • Autoimmune disorders like systemic lupus erythematosus, rheumatoid arthritis, and Sjögren's syndrome are often associated with T-suppressor cell defects.
    • Thymosin, fraction 5, is a polypeptide extract from thymus that modulates T-cell function.

    Purpose of the Study:

    • To investigate the therapeutic potential of thymosin, fraction 5, in patients with autoimmune disorders.
    • To assess the effect of thymosin on T lymphocyte levels and serum cytotoxicity in these patients.

    Main Methods:

    • Parenteral administration of thymosin, fraction 5, to five patients with autoimmune disorders for 2-35 months.
    • Monitoring of circulating T lymphocyte counts and serum cytotoxicity assays using mouse thymocytes.

    Related Experiment Videos

    Main Results:

    • All patients showed an increase in circulating T lymphocytes.
    • Initial positive serum cytotoxicity assays declined during treatment, reaching zero in all patients.
    • Clinical improvement was observed in three patients; one showed disease stabilization.

    Conclusions:

    • Parenteral thymosin, fraction 5, may be a beneficial treatment for certain autoimmune disorders by restoring T-suppressor function.
    • The observed reduction in serum cytotoxicity and clinical improvements suggest thymosin's immunomodulatory effects.
    • Thymosin, fraction 5, was well-tolerated with no observed adverse effects in this patient cohort.