[Pharmacological studies of Bulgarian gonadotropin preparations]

Experiments were carried out to prove the influence of SJK gonadotropic preparations (native and lyophilized), gravohormone and luteosiman, on the functional state of the central, the cardio-vascular and the respiratory systems, as well as that of the smooth musculature. It was proved that in doses under 20 MUI/kg t these preparations have no unfavorable effect upon the function of the cardio-vascular system (experiments were carried out on frog's hearts eliminated, on blood vessels of eliminated rabbit's ears and the hind limbs of frogs, on the blood pressure of cats and hens), upon the breathing (experiments on cats), the central nervous system and the muscular tonus (experiments on mice). In high dose SJK decreases blood pressure by slightly increasing in that direction the influence of histamine and acetylcholine. Breathing becomes uneven, stronger and accelerated. The muscular tonus is characterized by depression and decrease. A tonic effect was observed with the uterus, as well as increased contractions of the latter. The gravohormone taken in high doses provoked a decrease in blood pressure, an abatement and a depression of the tonus and motility of the eliminated uterus without any substantial changes of the rhythm and frequency of respiratory movements. In low and high doses (0,2, 20 and 60, 160 UI/kg t) it decreased the blood pressure of the narcotized hens, strengthened and increased the tonus of the motor activity of the uterus, which was probably due to residues of oxytocin.