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Ampicillin-resistant Haemophilus influenzae colonizing ambulatory children
American Journal of Diseases of Children (1960)
|May 1, 1981
Summary
Ampicillin-resistant Haemophilus influenzae is present in 3% of children, with resistance linked to prior ampicillin or amoxicillin exposure. This highlights the impact of antibiotic use on bacterial resistance in children.
Area of Science:
- Pediatric infectious diseases
- Microbiology
- Antimicrobial resistance
Background:
- Haemophilus influenzae is a common cause of childhood infections.
- Antibiotic resistance, particularly to ampicillin, is a growing concern.
- Understanding resistance patterns is crucial for effective treatment.
Purpose of the Study:
- To determine the prevalence of ampicillin-resistant Haemophilus influenzae in ambulatory children.
- To identify factors associated with the carriage of these resistant strains.
Main Methods:
- Throat cultures were collected from 305 ambulatory children.
- Prevalence of resistant strains was calculated.
- Statistical analysis was performed to identify associated factors.
Main Results:
- Ampicillin-resistant Haemophilus influenzae was found in 3% of children (12% of isolates).
- Prior ampicillin or amoxicillin exposure within six months was significantly associated with resistance (9% vs. 1.4%).
- No significant association was found with age, sex, otitis history, or day-care exposure.
Conclusions:
- Ampicillin/amoxicillin use is a significant factor in the carriage of ampicillin-resistant Haemophilus influenzae.
- Further research is needed to assess the impact of newer antibiotics on resistance development.