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Immunological phenotypes of human leukemias of the B-cell lineage
The recent results are summarized of some immunological studies of various human leukemias of the B-cell lineage. The study of pre-B leukemias has outlined the diversity of immunoglobulin expression in leukemic cells resembling B-lymphocyte precursors and has provided insights into the biology of the progenitors of hematopoietic cells. Acute leukemia with Burkitt cells represents a very homogeneous group close to classical Burkitt's lymphoma. Mitogens are able to induce in vitro differentiation of leukemic cells from chronic lymphocytic-B leukemia and from hairy cell leukemia. Hairy cells become able to express new phenotypic characteristics after stimulation by phytohemagglutinin.
The recent results are summarized of some immunological studies of various human leukemias of the B-cell lineage. The study of pre-B leukemias has outlined the diversity of immunoglobulin expression in leukemic cells resembling B-lymphocyte precursors and has provided insights into the biology of the progenitors of hematopoietic cells. Acute leukemia with Burkitt cells represents a very homogeneous group close to classical Burkitt's lymphoma. Mitogens are able to induce in vitro differentiation of leukemic cells from chronic lymphocytic-B leukemia and from hairy cell leukemia. Hairy cells become able to express new phenotypic characteristics after stimulation by phytohemagglutinin.