Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunoregulation by alpha 1 antitrypsin

S N Breit, J P Robinson, E Luckhurst

    Journal of Clinical & Laboratory Immunology
    |February 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Cleaning lateral morphological features of the root canal: the role of streaming and cavitation.

    International endodontic journal·2017
    Same author

    HBEGF promotes gliomagenesis in the context of Ink4a/Arf and Pten loss.

    Oncogene·2017
    Same author

    Activated MEK cooperates with Cdkn2a and Pten loss to promote the development and maintenance of melanoma.

    Oncogene·2017
    Same author

    The effect of deprivation on the incidence of mandibular fractures in a British city.

    The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·2016
    Same author

    Medical supply on contingency military operations: experience from Operation GRITROCK.

    Journal of the Royal Naval Medical Service·2016
    Same author

    Comparison of International Reference Values for Bone Speed of Sound in Pediatric Populations: Meta-analysis.

    Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry·2015
    Same journal

    Policy and science of FMD control: the stakeholders' contribution to decision making. A call for integrated animal disease management.

    Journal of clinical & laboratory immunology·2006
    Same journal

    An informative case of Graves' disease with implications for schizophrenia.

    Journal of clinical & laboratory immunology·2006
    Same journal

    Increase of circulating CD8+CD57+ lymphocytes after measles infection but not after measles vaccination.

    Journal of clinical & laboratory immunology·2006
    Same journal

    Review: immunomodulatory activity of pregnancy-associated plasma protein-A.

    Journal of clinical & laboratory immunology·2004
    Same journal

    Antibodies to Acinetobacter bacteria and bovine brain peptides, measured in bovine spongiform encephalopathy (BSE) in an attempt to develop an ante-mortem test.

    Journal of clinical & laboratory immunology·2004
    Same journal

    Principles of autoimmune disease: pathogenesis, genetics and specific immunotherapy.

    Journal of clinical & laboratory immunology·2004
    See all related articles

    Alpha 1 antitrypsin (alpha 1 AT) deficiency, a common genetic disorder, is linked to inflammatory conditions. Studies show immune system hyperreactivity in severe alpha 1 AT deficiency, potentially contributing to disease development.

    Area of Science:

    • Immunology
    • Genetics
    • Pulmonology

    Background:

    • Alpha 1 antitrypsin (alpha 1 AT) deficiency is a prevalent genetic disorder affecting approximately 10% of the population.
    • This deficiency is associated with an increased risk of numerous inflammatory and immunologic disorders, including rheumatoid arthritis, systemic lupus erythematosus, and emphysema.

    Purpose of the Study:

    • To investigate the immunologic function in individuals with severe alpha 1 AT deficiency.
    • To explore the potential link between immune system abnormalities and disease predisposition in these patients.

    Main Methods:

    • Assessed serum-mediated lymphocyte response to PHA (phytohemagglutinin).
    • Measured zymosan activation of mononuclear cells and neutrophils via chemiluminescence.
    • Evaluated delayed hypersensitivity responses and complement component levels (Factor B, C3, C5).

    Related Experiment Videos

    Main Results:

    • Demonstrated enhanced lymphocyte response to PHA mediated by serum.
    • Observed increased zymosan activation of mononuclear cells and neutrophils.
    • Found accelerated delayed hypersensitivity responses and elevated levels of Factor B, C3, and C5, with normal immunoglobulin and other complement components.

    Conclusions:

    • Abnormalities in immunoregulation, including a tendency towards hyperreactivity, were identified in patients with severe alpha 1 AT deficiency.
    • These immune dysregulations may contribute to the predisposition to various inflammatory and immunologic diseases observed in alpha 1 AT deficiency.