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Related Experiment Videos

Digoxin compliance in patients from general practice

G D Johnston, D G McDevitt

    British Journal of Clinical Pharmacology
    |October 1, 1978
    PubMed
    Summary
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    Nearly half of patients on digoxin therapy showed poor compliance, evidenced by changes in plasma levels and missed doses. This highlights a significant issue in general practice medication adherence.

    Area of Science:

    • Pharmacology
    • Clinical Pharmacy
    • Patient Adherence Studies

    Background:

    • Digoxin is a critical medication for managing various cardiac conditions.
    • Ensuring patient compliance with digoxin therapy is essential for therapeutic efficacy and patient safety.
    • Non-compliance can lead to suboptimal treatment outcomes and increased healthcare costs.

    Purpose of the Study:

    • To assess the level of compliance among patients receiving digoxin therapy in a general practice setting.
    • To identify the prevalence of non-compliance with prescribed digoxin dosage.
    • To evaluate the effectiveness of different methods in estimating medication adherence.

    Main Methods:

    • A cohort of fifty patients on digoxin therapy in general practice were studied.

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  • Compliance was assessed using two primary methods: plasma digoxin concentration monitoring and tablet counting.
  • Plasma digoxin levels were measured before and after a 10-day period of monitored digoxin intake.

    • Main Results:

    • Twenty patients (40%) were identified as non-compliant based on monitored intake and tablet counts.
    • Twelve patients showed significant increases in plasma digoxin concentrations (>0.4 ng/ml) during monitored intake.
    • Eight patients consumed less than 80% of their prescribed digoxin tablets, and three had initially undetectable levels that rose substantially.

    Conclusions:

    • A substantial proportion of patients (46%) exhibited non-compliance with their prescribed digoxin dosage in general practice.
    • The study underscores the challenges in maintaining medication adherence for digoxin therapy outside of hospital settings.
    • Combined methods of plasma concentration monitoring and tablet counting provide a robust assessment of digoxin compliance.