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Related Experiment Videos

Can experimental B cell tolerance serve as a model for self tolerance?

E Diener, U E Diner, R C von Borstel

    Annals of the New York Academy of Sciences
    |January 1, 1982
    PubMed
    Summary

    The mature and immature immune systems can distinguish between tolerogenic and nontolerogenic antigens. Chemical modification of carriers abrogated tolerogenicity, demonstrating immune system discrimination capabilities in both adult and neonatal mice.

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    Area of Science:

    • Immunology
    • Immunological Tolerance

    Background:

    • The immune system's ability to distinguish between self and non-self is crucial for maintaining health.
    • Immunological tolerance is a state of unresponsiveness to specific antigens.

    Purpose of the Study:

    • To investigate the capacity of mature and immature immune systems to differentiate between tolerogenic and nontolerogenic hapten-carrier conjugates.
    • To explore the role of chemical modifications in altering antigen tolerogenicity.

    Main Methods:

    • Induction of hapten-specific tolerance in adult B cells using nonimmunogenic dinitrophenylated polymers.
    • Chemical modification (oxidation and reduction) of carrier molecules to alter tolerogenicity.
    • Testing immune responses in neonatal and adult mice, including those reconstituted with fetal liver cells.

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    Main Results:

    • Chemical modification of carriers abrogated tolerogenicity without affecting molecular weight or binding avidity.
    • Both mature and immature immune systems demonstrated the ability to discriminate between tolerogenic and nontolerogenic antigen forms.
    • Neonatally induced tolerance was found to be irreversible for TNP-HGG but reversible for TNP-BSA.

    Conclusions:

    • The findings challenge the clonal abortion hypothesis as the sole mechanism for tolerance induction.
    • Immune systems, both mature and immature, possess sophisticated mechanisms for discriminating antigen properties beyond simple binding avidity.