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Updated: Aug 2, 2026

A Bioinformatics Pipeline for Investigating Molecular Evolution and Gene Expression using RNA-seq
Published on: May 28, 2021
Abstract:
General idea of a gene as a part of the hereditary molecule DNA permits to correlate various alleles states of a gene to various energy states of the hereditary molecule. Hereditary molecule under the action of a random force moves along its energy states. So far as the number of individuals in a population usually is very big, such motion of a gene in energy space resembles random motion of the Brownian particle in liquid. Here the process of striving hereditary molecule for minimum potential energy will correspond to the slow precipitation of particles under the effect of the force of gravity. Therefore, gene diffusion in energy space is described by the Focker--Plank's equation. The solution of this equation shows the time evolution of the distribution of genes alleles states within the limits of an isolated population.
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