[HCG and SP-1 in normal pregnancy and in high-risk early pregnancy]

For the prognosis in early pregnancies associated with vaginal bleeding ultra-sonography and bio-chemical methods are prominent today. In a retrospective study of 90 determinations of both chorionic gonadotrophin (HCG) and SP-1 (pregnancy specific protein-1, TGB PS beta G) the prognostic value of these two glyco-proteins synthesized in the trophoblast were compared. Both parameters were reliable for the prognosis of threatened abortion, correlated well with each other and showed excellent statistical results regarding sensitivity, specificity and prognostic value regarding abortion or a chance for continuation of the pregnancy. Both were very efficient. These results show that HCG and SP-1 are equally well suited for the serial evaluation of trophoblast function in early pregnancy. Their value compared to ultra-sonography needs further studies.