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Geographical variation in disease presentation. Does it constitute a problem and can information science help?

F T de Dombal, J R Staniland, S E Clamp

    Medical Decision Making : an International Journal of the Society for Medical Decision Making
    |January 1, 1981
    PubMed
    Summary
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    Geographical variations in disease presentation significantly impact automated clinical decision-making systems. Large multinational databases with standardized definitions are urgently needed to ensure system accuracy and patient safety.

    Area of Science:

    • Medical Informatics
    • Gastroenterology
    • Clinical Decision Support

    Background:

    • Automated clinical decision-making systems rely on consistent disease presentation data.
    • Geographical variations in disease presentation pose a challenge to the universal applicability of these systems.

    Purpose of the Study:

    • To assess the impact of geographical variation on disease presentation.
    • To evaluate the implications for automated clinical decision-making systems.

    Main Methods:

    • Analysis of data from World Organization of Gastroenterology studies.
    • Inclusion of patient cohorts with inflammatory bowel disease, acute abdominal pain, and upper GI bleeding.

    Main Results:

    • Significant geographical variations observed in disease presentation, affecting both disease probability and symptom likelihood.

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  • These variations present a substantial threat to the reliability of automated decision-making systems.

    • Conclusions:

    • Urgent need for large-scale, multinational case series with reproducible disease and symptom definitions.
    • Such databases are crucial for validating and improving automated clinical decision-making tools.