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Updated: Aug 10, 2026

Isolation and Flow Cytometric Characterization of Murine Small Intestinal Lymphocytes
08:14

Isolation and Flow Cytometric Characterization of Murine Small Intestinal Lymphocytes

Published on: May 8, 2016

[Immunopathology of the digestive apparatus in infancy]

M Shiner

    La Pediatria Medica E Chirurgica : Medical and Surgical Pediatrics
    |July 1, 1982
    PubMed

    Insights

    Infants gain immune competence in the neonatal period via gut antigens interacting with lymphoid tissues. Immune deficiencies contribute to various gastrointestinal diseases in infants and children.

    Area of Science:

    • Immunology
    • Gastroenterology
    • Neonatal Medicine

    Context:

    • Infant immune system development relies on gut-associated lymphoid tissues (GALT) for antigen exposure.
    • Neonatal period is critical for establishing immunological competence through enteric antigen passage.
    • Gut-associated lymphoid tissues, including Peyer's patches and appendix, are key sites for immune development.

    Purpose:

    • To explore the role of immune deficient mechanisms in neonatal and childhood gastrointestinal diseases.
    • To discuss how immune reactions contribute to the pathogenesis of specific GI disorders.
    • To elucidate the immunological basis of various infant and childhood gastrointestinal conditions.

    Summary:

    • Infants develop immunological competence through antigen exposure in the neonatal gut via GALT.
    • Immune deficiencies are implicated in several gastrointestinal diseases presenting in infancy and childhood.
    • The abstract discusses the mechanisms by which immune reactions drive the pathogenesis of these conditions.

    Impact:

    • Highlights the link between early life gut immunology and long-term gastrointestinal health.
    • Provides insights into the pathogenesis of critical infant GI diseases like necrotising enterocolitis.
    • Informs potential therapeutic strategies targeting immune mechanisms in pediatric gastroenterology.

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