Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Changes in lymphoblastic transformation in preleukemic AKR/J mice]

M C Alonso, A Torres, R Solana

    Revista Espanola De Oncologia
    |January 1, 1982
    PubMed
    Summary

    This study shows AKR/J mice have a declining immune response with age, unlike BALB/C mice. However, older AKR/J mice exhibit a temporary immune boost, highlighting age-related immune system changes.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Pulmonary complications in patients with haematological malignancies treated at a respiratory ICU.

    The European respiratory journal·1998
    Same author

    Respiratory mechanics in ventilated COPD patients: forced oscillation versus occlusion techniques.

    The European respiratory journal·1998
    Same author

    Subclavian vascular access stenosis in dialysis patients: natural history and risk factors.

    Journal of the American Society of Nephrology : JASN·1998
    Same author

    ATP-sensitive K+ channel blocker glibenclamide and diaphragm fatigue during normoxia and hypoxia.

    Journal of applied physiology (Bethesda, Md. : 1985)·1998
    Same author

    Prognostic significance of p53 gene mutations in squamous cell carcinoma of the lung.

    Oncology reports·1998
    Same author

    [Behavioral evaluation of the unilateral lesion model in rats using 6-hydroxydopamine. Correlation between the rotations induced by D-amphetamine, apomorphine and the manual dexterity test].

    Revista de neurologia·1998

    Area of Science:

    • Immunology
    • Aging Research
    • Mouse Models

    Background:

    • The immune system's efficacy changes throughout an organism's lifespan.
    • Understanding age-related immune decline is crucial for health research.

    Purpose of the Study:

    • To investigate the age-related immune response in AKR/J mice.
    • To compare immune function between AKR/J and BALB/C mouse strains over time.
    • To identify factors influencing immune cell activity.

    Main Methods:

    • Utilized the phytohemagglutinin (PHA)-induced lymphoblastic transformation test.
    • Compared immune responses in AKR/J and BALB/C mice at various ages (15, 25, 35, 45 weeks).
    • Assessed lymphocyte proportions, organ weights (thymus, spleen), and PHA response, with and without macrophages.

    Main Results:

    • AKR/J mice showed significantly lower lymphoblastic transformation at 15, 25, and 35 weeks compared to BALB/C mice.
    • At 45 weeks, AKR/J mice exhibited increased lymphocytes in thymus/spleen, organ weight gain, and augmented PHA response.
    • Macrophage removal abolished PHA-induced lymphoblastic transformation in both strains at all ages.

    Conclusions:

    • AKR/J mice display a unique age-related immune response pattern, with a late-life augmentation.
    • The study underscores the critical role of macrophages in T-cell activation via PHA stimulation.
    • Findings contribute to understanding immune senescence and potential age-related immune dysregulation.

    Related Experiment Videos