Treatment of urinary infections with cefadroxil: controlled comparison of high-compliance oral dosage regimens

The efficacy and tolerability of cefadroxil were assessed in a controlled comparison of high-compliance oral dosage regimens among 100 patients with urinary tract infections. Each patient was randomly assigned to one of three cefadroxil treatment groups: 2,000 mg. once daily, 1,000 mg. once daily, or 1,000 mg. twice daily. Urine cultures at five to nine days post-treatment revealed cures in 27 of 36 patients in the 2,000-mg. daily group, 32 of 36 patients in the 1,000-mg. daily group, and 27 of 28 patients taking 1,000 mg. twice daily. Recurrence rates were extremely low in all treatment groups, and only 3 patients had evidence of limited side effects. The benefits of a convenient and readily understood dosage schedule are discussed.