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Radiochromium distribution in thyroid and parathyroid deficiency
The American Journal of Clinical Nutrition
|January 1, 1980
Summary
Thyroid hormone significantly impacts chromium (Cr) distribution in rats, affecting body retention and tissue levels. Removal of the thyroid and parathyroid glands (TPTX) increased Cr retention, an effect reversed by thyroxin replacement.
Area of Science:
- Endocrinology
- Trace Element Metabolism
- Physiology
Background:
- Thyroid hormones play a crucial role in metabolic regulation.
- The influence of thyroid hormones on trace element transport, specifically chromium, is not fully understood.
- Thyroparathyroidectomy (TPTX) provides a model to study the effects of thyroid and parathyroid hormone deficiency.
Purpose of the Study:
- To investigate the effect of thyroid and parathyroid hormones on the body retention and tissue distribution of a chromium (Cr) tracer.
- To determine if thyroxin, calcitonin, or parathyroid hormone replacement influences 51Cr distribution in TPTX rats.
Main Methods:
- Thyroparathyroidectomized (TPTX) rats and control rats were used.
- Intravenous injection of a 51Cr tracer was administered.
- Body retention and tissue distribution of 51Cr were measured in serum and various tissues three days post-injection.
Main Results:
- TPTX rats exhibited significantly increased total body 51Cr retention and elevated serum and tissue 51Cr levels (40-240%).
- Tissue:serum 51Cr ratios were consistently decreased in TPTX rats.
- Thyroxin replacement normalized 51Cr distribution in most tissues, while calcitonin and parathyroid hormone had no significant effect.
Conclusions:
- Thyroid hormone activity, not calcitonin or parathyroid hormone, influences the distribution of 51Cr in the body.
- These findings support the hypothesis that thyroid hormone regulates cellular chromium transport.