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Benign mucous membrane pemphigoid in association with internal malignancy

K E Greer, B E Beacham, F C Askew

    Cutis
    |February 1, 1980
    PubMed
    Summary

    A rare case links benign mucous membrane pemphigoid, a blistering disorder, with advanced lung cancer. This association, though uncommon, suggests a potential connection between autoimmune blistering diseases and internal malignancies.

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    Area of Science:

    • Dermatology
    • Oncology
    • Pathology

    Background:

    • Benign mucous membrane pemphigoid (BMMP) is a rare autoimmune blistering disease primarily affecting mucous membranes.
    • The association between autoimmune blistering diseases and internal malignancy is an area of ongoing research.
    • Bullous pemphigoid (BP), another autoimmune blistering disease, has a more established, though still debated, link to internal cancers.

    Observation:

    • A patient diagnosed with benign mucous membrane pemphigoid was subsequently found to have metastatic carcinoma of the lung.
    • This case represents a rare instance of co-occurrence between BMMP and a significant internal malignancy.

    Findings:

    • The co-occurrence of BMMP and metastatic lung carcinoma in this patient is noteworthy.
    • Few documented cases report a similar association, highlighting its rarity.

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    Implications:

    • The findings suggest that a potential, albeit infrequent, association between benign mucous membrane pemphigoid and internal malignancy, specifically lung cancer, cannot be entirely dismissed.
    • Further research and case reporting are warranted to explore this possible link more extensively.
    • This case underscores the importance of considering underlying systemic conditions in patients presenting with rare dermatological disorders.