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Histocompatibility antigens (HLA) and uveitis

Y Scharf, S Zonis

    Survey of Ophthalmology
    |January 1, 1980
    PubMed
    Summary

    Human Leukocyte Antigen (HLA) B 27 is strongly linked to acute anterior uveitis, particularly with rheumatic disorders like ankylosing spondylitis. Further research is needed to fully understand uveitis pathogenesis and prevention.

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    Area of Science:

    • Immunogenetics
    • Ophthalmology
    • Rheumatology

    Background:

    • Uveitis pathogenesis is complex, involving genetic and environmental factors.
    • Histocompatibility (HLA) antigens play a role in understanding immune-mediated diseases.
    • Acute anterior uveitis is frequently associated with rheumatic conditions.

    Purpose of the Study:

    • To investigate the association between specific Human Leukocyte Antigen (HLA) antigens and various forms of uveitis.
    • To explore the role of HLA-B 27 in the pathogenesis and diagnosis of acute anterior uveitis and related conditions.

    Main Methods:

    • Review and analysis of studies investigating HLA antigen associations with uveitis.
    • Clinical observation and genetic typing in patients with uveitis and rheumatic disorders.

    Main Results:

    • HLA-B 27 is present in 98% of acute anterior uveitis cases associated with ankylosing spondylitis.
    • HLA-B 27 is associated with 43% of acute anterior uveitis cases without systemic disease.
    • Specific HLA antigens are linked to other uveitis forms: HLA-B 27 (Reiter's disease), HLA-B 5 (Behcet's syndrome), HLA-Bw 22J (VKH syndrome), HLA-B 7 (ocular histoplasmosis).

    Conclusions:

    • HLA antigen typing, particularly HLA-B 27, is valuable for diagnosing and differentiating types of uveitis and associated rheumatic diseases.
    • While significant associations have been identified, further research is essential to fully elucidate the pathogenesis of uveitis and develop preventive strategies.

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