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Pluripotent hemopoietic stem cells in murine postmortem bone marrow

P I Liu, K C Poon, L Crook

    Annals of Clinical and Laboratory Science
    |January 1, 1980
    PubMed
    Summary

    Murine bone marrow cells, even 12 hours postmortem, contain viable pluripotent hematopoietic stem cells. These cells can repopulate the spleen, suggesting potential for cadaveric bone marrow transplantation in treating blood disorders.

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    Area of Science:

    • Hematology
    • Stem Cell Biology
    • Transplantation Medicine

    Background:

    • Bone marrow cells undergo degeneration postmortem.
    • The viability and function of postmortem bone marrow stem cells are not well understood.

    Purpose of the Study:

    • To investigate the presence and proliferative capacity of hematopoietic stem cells in murine bone marrow 12 hours postmortem.
    • To assess the potential of using postmortem bone marrow for transplantation.

    Main Methods:

    • Infusion of 12-hour postmortem murine bone marrow cells into irradiated mice.
    • Analysis of spleen for colony formation (erythrocytic, granulocytic, megakaryocytic, mixed).

    Main Results:

    • Postmortem bone marrow cells formed erythrocytic, granulocytic, megakaryocytic, and mixed colonies in the spleen.

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  • Demonstrated the presence of pluripotent hematopoietic stem cells and their proliferative capability in 12-hour postmortem bone marrow.

    • Conclusions:

    • 12-hour postmortem murine bone marrow contains functional pluripotent hematopoietic stem cells.
    • Cadaveric bone marrow transplantation is a potential therapeutic strategy for hematologic disorders.