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The measles virus

V M Zhdanov

    Molecular and Cellular Biochemistry
    |January 16, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Measles virus causes acute and persistent infections, affecting the central nervous system and organs. Molecular studies explore its role in diseases like subacute sclerosing panencephalitis.

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    Area of Science:

    • Virology
    • Immunology
    • Pathogenesis

    Background:

    • Measles is a widespread viral infection, a significant cause of mortality in tropical regions.
    • The measles virus (genus Morbillivirus, family Paramyxoviridae) comprises six polypeptides, including surface glycoproteins with hemagglutinating and hemolytic activities.
    • Viral replication follows typical Paramyxovirus patterns.

    Purpose of the Study:

    • To investigate the molecular mechanisms underlying measles virus persistent infections.
    • To elucidate the pathogenesis of diseases associated with measles virus, such as subacute sclerosing panencephalitis (SSPE).

    Main Methods:

    • Analysis of measles virus virion composition, including polypeptides and surface proteins.
    • Study of measles virus replication processes.

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  • Investigation of molecular mechanisms driving persistent infections.

    • Main Results:

    • Identified six viral polypeptides, including a glycoprotein, two surface proteins, and a polymerase.
    • Confirmed similarities in replication to other Paramyxoviruses.
    • Characterized persistent infection as a key feature affecting the central nervous system and internal organs.

    Conclusions:

    • Molecular mechanisms of measles virus persistent infection are crucial for understanding associated pathologies.
    • Measles virus may be implicated in the pathogenesis of SSPE, systemic lupus erythematosus, and other conditions.
    • Further research into measles virus molecular biology can illuminate disease mechanisms.