Various lipopolysaccharides reduce adhesion of periodontal ligament fibroblasts

The interaction of LPS from Bacteroides fragilis, Escherichia coli, Salmonella typhimurium and lipid A from S. typhimurium with adhesion of human periodontal cells on plastic surfaces has been studied. The results showed that LPS and lipid A reduced adhesion already after 5 min at concentrations from 5 to 200 microgram/ml without influencing cell viability. It could be demonstrated that LPS and lipid A interact with both the cell and the substratum surface. Lipid A from S. typhimurium was more potent than any of the LPS used.