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Related Experiment Videos

Plasma secretin in neonates

A Lucas, T E Adrian, S R Bloom

    Acta Paediatrica Scandinavica
    |March 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Plasma secretin levels are high in newborns but decrease with age. Enteral feeding influences these changes, with preterm infants showing a significant postprandial secretin response by 24 days.

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    Area of Science:

    • Neonatal Physiology
    • Gastrointestinal Hormones
    • Pediatric Endocrinology

    Background:

    • Plasma secretin levels in newborns differ significantly from adults.
    • Early life feeding practices may impact hormonal development.

    Purpose of the Study:

    • To investigate plasma secretin levels in term and preterm infants.
    • To determine the influence of enteral feeding on secretin concentrations.

    Main Methods:

    • Measurement of plasma secretin in 96 term and 158 preterm infants at various postpartum ages.
    • Comparison of secretin levels in fed versus unfed infants.
    • Analysis of correlations with blood glucose and insulin.

    Main Results:

    • Both term and preterm infants had high plasma secretin at birth, declining towards adult levels.

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  • Unfed preterm infants maintained high basal secretin.
  • A significant postprandial secretin increase was observed in preterm infants by 24 days.

    • Conclusions:

    • Plasma secretin undergoes significant adjustments in early infancy.
    • Enteral feeding appears to be a key factor influencing these adjustments.
    • Developmental changes in secretin regulation are evident in the neonatal period.