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Related Experiment Videos

Proteinuria during long-term captopril therapy

D B Case, S A Atlas, J A Mouradian

    JAMA
    |July 25, 1980
    PubMed
    Summary
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    Captopril can cause proteinuria in hypertensive patients, but it often resolves even with continued treatment. Some cases may persist, indicating potential kidney issues.

    Area of Science:

    • Nephrology
    • Pharmacology
    • Internal Medicine

    Background:

    • Hypertension is a significant global health concern.
    • Captopril is an angiotensin-converting enzyme (ACE) inhibitor commonly used to manage hypertension.
    • ACE inhibitors can have various effects on renal function.

    Purpose of the Study:

    • To investigate the incidence and characteristics of proteinuria in hypertensive patients treated with captopril.
    • To determine the course and resolution patterns of captopril-induced proteinuria.
    • To identify potential risk factors or associations with persistent proteinuria.

    Main Methods:

    • Observational study of 81 hypertensive patients receiving captopril for at least four months.
    • Monitoring of proteinuria levels (protein excretion > 200 mg/24 hr).

    Related Experiment Videos

  • Assessment of proteinuria changes over time and correlation with clinical parameters and renal biopsy findings.

    • Main Results:

    • Proteinuria developed in 6 out of 81 patients (7.4%) within four months of captopril therapy.
    • In four patients, proteinuria subsided despite continued treatment, with complete resolution in two.
    • Two patients experienced persistent proteinuria, accompanied by hypoalbuminemia, hypercholesterolemia, and mild membranous nephropathy.

    Conclusions:

    • Captopril can induce transient proteinuria in a subset of hypertensive patients.
    • Proteinuria often resolves spontaneously during ongoing captopril treatment.
    • Persistent proteinuria may indicate underlying renal pathology and warrants further investigation.